Intranuclear defect in beta-globin mRNA accumulation due to a premature translation termination codon
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چکیده
منابع مشابه
Intranuclear defect in beta-globin mRNA accumulation due to a premature translation termination codon.
We have analyzed a cloned beta O-thalassemia (beta O-thal) gene from a patient doubly heterozygous for hemoglobin Lepore and beta O-thalassemia. Studies of 3H-uridine incorporation into beta-globin mRNA in this patient's erythroblasts suggested an intranuclear defect in both beta and Lepore (delta beta) mRNA synthesis, as did S1 nuclease analysis of nuclear RNA. However, the nucleotide sequence...
متن کاملIntranuclear Defect in 9 - Globin mRNA Accumulation Due to a Premature Translation Termination Codon
We have analyzed a cloned #{176}-thalassemia ($#{176}-thal) gene from a patient doubly heterozygous for hemoglobin Lepore and $#{176}-thalassemia. Studies of 3H-uridine incorporation into 9-globin mRNA in this patient’s erythroblasts suggested an intranuclear defect in both $ and Lepore (#{246} ) mRNA synthesis, as did S nuclease analysis of nuclear RNA. However, the nucleotide sequence of the ...
متن کاملIntranuclear Defect in 9 - Globin mRNA Accumulation Due to a
We have analyzed a cloned #{176}-thalassemia ($#{176}-thal) gene from a patient doubly heterozygous for hemoglobin Lepore and $#{176}-thalassemia. Studies of 3H-uridine incorporation into 9-globin mRNA in this patient’s erythroblasts suggested an intranuclear defect in both $ and Lepore (#{246} ) mRNA synthesis, as did S nuclease analysis of nuclear RNA. However, the nucleotide sequence of the ...
متن کاملIntranuclear degradation of nonsense codon-containing mRNA.
Most vertebrate mRNAs with premature termination codons (PTCs) are specifically recognized and degraded by a process referred to as nonsense-mediated mRNA decay (NMD) while still associated with the nucleus. However, it is still a matter of debate whether PTCs can be identified by intranuclear scanning or only by ribosomes on the cytoplasmic side of the nuclear envelope. Here we show that inhib...
متن کاملThe terminator “Non-sense mediate mRNA decay”: Its role in the termination of intron containing a premature termination codon
Human genes are composed of exons and interrupted by introns that must be removed by splicing to create a translatable mRNA. Alternative splicing is a vital pathway to regulate gene expression and increase the protein diversity.1,2 In addition to skipping and inclusion of variable exons and usage of alternative splice sites,3 intron retention is a third example of alternative splicing, whereby ...
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ژورنال
عنوان ژورنال: Blood
سال: 1984
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v64.1.13.bloodjournal64113